This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors. 


медицина / здравоохранение

фармакология

Thermodynamics and Kinetics of Drug Binding

Pharmacokinetics and Metabolism in Drug Design

Chemokine Receptors as Drug Targets

Protein-Ligand Interactions

In vivo Models for Drug Discovery

Reactive Drug Metabolites

Drug Bioavailability

Antiviral Drug Strategies

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современная русская литература

современные любовные романы

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литература 19 века

научная фантастика

юмористическая литература

Thermodynamics and Kinetics of Drug Binding

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